论文
1. Shuliang Chen, Xiao Yu, Yi Wang, Cong Zeng, Shun Li, Ruangang Pan, Yuanyuan Cao, Ting Fang, Mingzhu Zhu, Min Wang and Deyin Guo*. VHL negatively regulates innate type I IFN response by targeting TRAF6 for degradation and disrupting the association of MAVS and TRAF3. (投稿中)
2. Panpan Hou#, Shuliang Chen#, Shilei Wang, Xiao Yu, Yu Chen, Meng Jiang,Ke Zhuang, Wenzhe Ho, Wei Hou, Jian Huang and Deyin Guo*. Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection. Sci Rep. 2015;5:15577. doi: 10.1038/srep15577. (co-first author)
3. Xiao Yu#, Shuliang Chen#, Panpan Hou, Min Wang, Yu Chen and Deyin Guo*. VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability. Biochem Biophys Res Commun. 2015;459:270-6. (co-first author)
4. Shuliang Chen, Ke Chen, Qinghua Zhang, Hanhua Cheng* and Rongjia Zhou*. Regulation of the transcriptional activation of the androgen receptor by the UXT binding protein VHL. Biochem J. 2013 Aug 21. Doi:10.1042/BJ20121711.
5. Shuliang Chen, Xiao Yu, Quan Lei, Lixin Ma* and Deyin Guo*. The SUMOylation of Zinc-Fingers and Homeoboxes 1 (ZHX1) Regulates its Stability and Transcriptional Repression Activity. J Cell Biochem. 2013 Oct;114(10):2323-33. doi: 10.1002/jcb.24579
专利
1.周荣家,程汉华,陈述亮。一种新的酵母双杂交方法及其应用。专利号:201110113663.0
2.郭德银,陈述亮,侯盼盼,陈宇。用于艾滋病基因治疗的CRISPR/Cas9重组慢病毒载体及其慢病毒。专利号:201410770508.X
3.郭德银,陈述亮,肖巧巧,刘哲鹏。一种可用于艾滋病基因治疗的CRISPR/SaCas9载体系统。专利号:201610056141.4
基金
1.UXT与β-catenin互作促进I型干扰素表达的分子机制研究/国家自然科学青年基金/23万/2015年1月至2017年12月/主持
2.CRISPR-Cas9编辑CCR5和CXCR4受体基因阻止HIV侵染/中国博士后基金一等资助/8万/2015年1月至2016年12月/主持
3.CRISPR-Cas9同时敲除CCR5和CXCR4受体基因抑制HIV感染/中国博士后基金特别资助/15万/2015年1月至2017年12月/主持
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